Investigation of Dual Stage Acridones as A Potent Malaria Treatment

Investigation of Dual Stage Acridones as A Potent Malaria Treatment

Website or Online Data - 2015
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The need for potent antimalarials to prevent the emergence of drug resistant Plasmodium falciparum is urgent. Discovery of novel acridone chemotypes have shown promise for a new antimalarial drug treatment. Presently, two acridone chemotypes have intrinsic antimalarial potency against chloroquine sensitive and multidrug resistant parasites. Acridones lacking an N10 side chain are known as chemotype I acridones, whereas, chemotype II acridones are defined as having an alkyl side chain at the same position. The N10 substitution of chemotype II acridones is thought to target heme and inhibit hemozoin formation within the parasite's digestive vacuole, and is known to provide synergistic effects with other antimalarials such as quinine
Publisher: San Rafael, Calif. : Dominican University of California, 2015
Characteristics: 1 volume (electronic resource)


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