Dual MTOR/HDAC Inhibition

Dual MTOR/HDAC Inhibition

Preclinical Development of A Novel Breast Cancer Therapy

Website or Online Data - 2013
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"This project examines the effects of combining a novel investigational inhibitor of both complexes MLN0128 that targets mTORC1 and mTORC2, and Trichostatin-A (TSA), a potent inhibitor of both class I and class II HDACs, on the viability, downstream signaling, and polysome assembly of human breast cancer cell lines of various receptor subtypes (HER2-/+ and/or ER -/+), as well as on nontransformed breast epithelial cells. Our data suggest that combining MLN0128 and TSA caused synergistic growth inhibition in almost all breast cancer cell lines tested." -- p.v
Publisher: San Rafael, California : Dominican University of California, 2013
Characteristics: 1 online resource (41 pages)


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